Nmb Gene Summary [Mouse]

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in satiety, reproduction and thermoregulation, as well as in stress, fear and other behavioral responses. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2016]

Details

Type
Retained Intron
Official Symbol
Nmb
Official Name
neuromedin B [Source:MGI Symbol;Acc:MGI:1915289]
Ensembl ID
ENSMUSG00000025723
Bio databases IDs NCBI: 68039 Ensembl: ENSMUSG00000025723
Aliases neuromedin B
Synonyms 3110023K12Rik, Neuromedin b, RGD1562710
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nmb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Bombesin-like peptide
  • G-protein-coupled receptor binding
  • hormone
  • protein binding

Pathways

Biological processes and signaling networks where the Nmb gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • dilated cardiomyopathy
  • sneeze
  • glioblastoma
  • glioblastoma cancer
  • small cell lung cancer
regulated by
regulates
role in cell
  • proliferation
  • depolarization
  • elevation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • neurites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Nmb gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of interleukin-6 production
  • positive regulation of interferon-alpha production
  • neuropeptide signaling pathway
  • arachidonic acid secretion
  • positive regulation of testosterone secretion
  • signal transduction
  • cell-cell signaling
  • positive regulation of hormone secretion
  • negative regulation of hormone secretion
  • positive regulation of osteoclast proliferation
  • elevation of cytosolic calcium ion concentration

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular region
  • neuron projection

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • neuropeptide hormone activity
  • neuromedin B receptor binding
  • hormone activity

Gene-Specific Assays for Results You Can Trust

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