Lin7a Gene Summary [Mouse]
Predicted to enable L27 domain binding activity; PDZ domain binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within inner ear development; neurotransmitter secretion; and synaptic vesicle transport. Located in basolateral plasma membrane. Is expressed in glans of male genital tubercle; lung; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin7a |
| Official Name | lin-7 homolog A (C. elegans) [Source:MGI Symbol;Acc:MGI:2135609] |
| Ensembl ID | ENSMUSG00000019906 |
| Bio databases IDs | |
| Aliases | lin-7 homolog A (C. elegans) |
| Synonyms | AI848705, LIN7, lin-7-Ba, lin-7 homolog A, crumbs cell polarity complex component, LOC100911013, LOC100911160, MALS-1, Mlin-7, TIP-33, Veli, VELI1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lin7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein domain specific binding
- protein binding
- PDZ domain
- PDZ-domain binding
- L27 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- androgenic alopecia
role in cell
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- detergent resistant lipid raft fraction
- cytoplasmic vesicle membrane
- cellular membrane
- vesicles
- basolateral membrane
- synapse
- perikaryon
- dendrites
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lin7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- macromolecular complex assembly
- synaptic vesicle transport
- maintenance of epithelial cell apical/basal polarity
- protein transport
- exocytosis
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- tight junction
- MPP7-DLG1-LIN7 complex
- cell-cell junction
- extracellular vesicular exosome
- synapse
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L27 domain binding