Adgrb1 Gene Summary [Mouse]
Enables several functions, including PDZ domain binding activity; lipopolysaccharide binding activity; and phosphatidylserine binding activity. Involved in several processes, including negative regulation of protein metabolic process; phagocytosis; and positive regulation of myoblast fusion. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including focal adhesion; phagocytic cup; and postsynaptic density. Is expressed in several structures, including brain; early conceptus; and reproductive system. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrb1 |
| Official Name | adhesion G protein-coupled receptor B1 [Source:MGI Symbol;Acc:MGI:1933736] |
| Ensembl ID | ENSMUSG00000034730 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor B1 |
| Synonyms | adhesion G protein-coupled receptor B1, B830018M07Rik, BAI1, Brain-specific angiogenesis inhibitor 1, GDAIF, mKIAA4089 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- Thrombospondin type 1 repeats
- phospholipid binding
- Thrombospondin type 1 domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- thrombospondin-1 motif
- GPCR-Autoproteolysis INducing (GAIN) domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- lipopolysaccharide binding
- PDZ-domain binding
- Adhesion GPCR B N-terminal region
- binding protein
- thrombospondin properdin-like repeat
- GPCR proteolysis site, GPS, motif
- Spondin-like TSP1 domain
- PDZ binding motif
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Adgrb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- chronic lymphocytic leukemia
- androgenic alopecia
- glioblastoma
- glioblastoma cancer
role in cell
- phosphorylation in
- proliferation
- migration
- activation in
- fusion
- size
- length
- development
- binding
- engulfment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- Extracellular Space
- perisynaptic region
- perinuclear region
- cellular membrane
- focal adhesions
- intercellular junctions
- postsynaptic membrane
- dendritic spines
- dendritic spine head
- synapse
- dendrites
- postsynaptic density
- plasma
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- defense response to Gram-negative bacterium
- G-protein coupled receptor signaling pathway
- signal transduction
- negative regulation of cell proliferation
- apoptotic cell clearance
- negative regulation of protein catabolic process
- peripheral nervous system development
- cell surface receptor signaling pathway
- cell adhesion
- engulfment of apoptotic cell
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- muscle organ development
- phagocytosis, recognition
- axonogenesis
- innate immune response
- regulation of synaptic plasticity
- negative regulation of protein ubiquitination
- negative regulation of endothelial cell migration
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- extracellular space
- cell-cell junction
- perinuclear region of cytoplasm
- focal adhesion
- dendritic spine
- membrane
- phagocytic cup
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- phosphatidylserine binding
- protein binding
- PDZ domain binding
- lipopolysaccharide binding