Il20ra Gene Summary [Mouse]
Enables interleukin-20 binding activity. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and regulation of bone resorption. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in epididymis; eye; and ileum. Orthologous to human IL20RA (interleukin 20 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il20ra |
| Official Name | interleukin 20 receptor, alpha [Source:MGI Symbol;Acc:MGI:3605069] |
| Ensembl ID | ENSMUSG00000020007 |
| Bio databases IDs | |
| Aliases | interleukin 20 receptor, alpha |
| Synonyms | CRF2-8, E230031K19, IL-20R1, IL-20R-alpha, IL-20R-α, interleukin 20 receptor, alpha, interleukin 20 receptor subunit alpha, interleukin 20 receptor subunit α, interleukin 20 receptor, α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il20ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- protein binding
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
- interleukin-20 binding
Pathways
Biological processes and signaling networks where the Il20ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- arthritis
- malaria
- collagen-induced arthritis
- muscle invasive bladder cancer
- endometriosis
role in cell
- differentiation
- activation in
- proliferation
- production in
- migration
- invasion by
- osteoclastogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il20ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- regulation of bone resorption
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-20 binding
- cytokine receptor activity