Diras1 Gene Summary [Mouse]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in central nervous system; olfactory epithelium; peripheral nervous system ganglion; and retina. Orthologous to human DIRAS1 (DIRAS family GTPase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Diras1 |
| Official Name | DIRAS family, GTP-binding RAS-like 1 [Source:MGI Symbol;Acc:MGI:2183442] |
| Ensembl ID | ENSMUSG00000043670 |
| Bio databases IDs | |
| Aliases | DIRAS family, GTP-binding RAS-like 1 |
| Synonyms | DIRAS family GTPase 1, DIRAS family, GTP-binding RAS-like 1, GBTS1, GTP-binding protein Di-Ras1, RIG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Diras1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- rotator cuff injury
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- growth
- activation in
- binding in
- transformation
- vacuolation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Diras1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- signal transduction
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding
- mitogen-activated protein kinase binding