Mybpc1 Gene Summary [Mouse]
Predicted to enable myosin binding activity. Predicted to be involved in sarcomere organization. Predicted to act upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Predicted to be active in M band. Is expressed in several structures, including brain; hindlimb; reproductive system; skeletal musculature; and urinary system. Used to study congenital myopathy. Human ortholog(s) of this gene implicated in congenital myopathy 16; distal arthrogryposis type 1B; and lethal congenital contracture syndrome 4. Orthologous to human MYBPC1 (myosin binding protein C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mybpc1 |
| Official Name | myosin binding protein C, slow-type [Source:MGI Symbol;Acc:MGI:1336213] |
| Ensembl ID | ENSMUSG00000020061 |
| Bio databases IDs | |
| Aliases | myosin binding protein C, slow-type |
| Synonyms | 8030451F13RIK, CMYO16, CMYP16, LCCS4, LOC105369939, MYBPCC, MYBPCS, myosin binding protein C1, myosin binding protein C, slow-type, MYOTREM, SKELETAL MUSCLE C-protein, ssMyBP-C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mybpc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tri-helix bundle domain
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- alanine-proline rich region
- myosin binding
- FNIII-like repeat
- cytoskeletal protein binding
- structural constituent of muscle
- structural constituent of cytoskeleton
- FN3
- Immunoglobulin like
- M-domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myopathy
- distal arthrogryposis type 1B
- experimental autoimmune myositis
- hereditary disorder
- idiopathic scoliosis
- congenital myopathy with tremor
- lethal congenital contractural syndrome type 4
- pancreatitis
- breast cancer
- kyphosis
role in cell
- quantity
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cytosol
- myofibrils
- I band
- m-bands
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mybpc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sarcomere organization
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- myosin filament
- cytosol
- M band
- myofibril
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- protein binding
- actin binding
- myosin binding
- titin binding