Ddit4 Gene Summary [Mouse]
Enables 14-3-3 protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; negative regulation of TOR signaling; and negative regulation of glycolytic process. Located in mitochondrion. Is expressed in several structures, including cerebral cortex subventricular zone; reproductive system; and retina nuclear layer. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddit4 |
| Official Name | DNA-damage-inducible transcript 4 [Source:MGI Symbol;Acc:MGI:1921997] |
| Ensembl ID | ENSMUSG00000020108 |
| Bio databases IDs | |
| Aliases | DNA-damage-inducible transcript 4 |
| Synonyms | 5830413E08Rik, Dig2, DKFZP564O2071, DNA-damage-inducible transcript 4, FLJ20500, REDD-1, Rtp801 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddit4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RTP801 C-terminal region
- protein binding
Pathways
Biological processes and signaling networks where the Ddit4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- breast cancer
- obesity
- insulin resistance
- hepatic steatosis
- abdominal aortic aneurysm
- pulmonary emphysema
- edema
- ulcerative colitis
- rheumatoid arthritis
role in cell
- expression in
- cell death
- apoptosis
- cellular infiltration by
- phosphorylation in
- activation in
- transformation
- differentiation
- cell cycle progression
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddit4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- negative regulation of glycolysis
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- brain development
- reactive oxygen species metabolic process
- nerve growth factor receptor signaling pathway
- neuron migration
- response to hypoxia
- apoptotic process
- defense response to virus
- cellular response to dexamethasone stimulus
- negative regulation of TOR signaling cascade
- intracellular signal transduction
- macromolecular complex disassembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- 14-3-3 protein binding