Dnm2

Predicted to enable several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in clathrin-coated pit and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; oocyte; sensory organ; and skin. Used to study centronuclear myopathy; cystic kidney disease; microcytic anemia; and myopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Dnm2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnm2 gene, providing context for its role in the cell.