Phlda1 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol phosphate binding activity. Acts upstream of or within glycoprotein biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb segment; respiratory system; and sensory organ. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phlda1 |
| Official Name | pleckstrin homology like domain, family A, member 1 [Source:MGI Symbol;Acc:MGI:1096880] |
| Ensembl ID | ENSMUSG00000020205 |
| Bio databases IDs | |
| Aliases | pleckstrin homology like domain, family A, member 1 |
| Synonyms | DT1P1B11, PHLDA, PHRIP, pleckstrin homology like domain family A member 1, pleckstrin homology-like domain, family A, member 1, PQ-RICH, Proline- and glutamine-rich, TDAG, TDAG51 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phlda1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neoplasia
- colorectal carcinoma
- toxic shock syndrome
- colorectal carcinomagenesis
- colorectal cancer
- methionine choline-deficient diet induced nonalcoholic fatty liver disease
- colorectal adenoma
- colorectal adenoma formation
- gastric epithelial cancer
role in cell
- cell death
- apoptosis
- growth
- activation in
- accumulation in
- proliferation
- expression in
- migration
- adhesion
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- vesicles
- cytosol
- nucleoplasm
- nucleoli
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phlda1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- FasL biosynthetic process
- apoptotic process
- positive regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic vesicle
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding