Mdm1 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Acts upstream of or within retina development in camera-type eye. Located in centriole; centrosome; and non-motile cilium. Is expressed in brain ependyma; retina inner nuclear layer; and retina outer nuclear layer. Used to study retinal degeneration. Orthologous to human MDM1 (Mdm1 nuclear protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mdm1 |
| Official Name | transformed mouse 3T3 cell double minute 1 [Source:MGI Symbol;Acc:MGI:96951] |
| Ensembl ID | ENSMUSG00000020212 |
| Bio databases IDs | |
| Aliases | transformed mouse 3T3 cell double minute 1 |
| Synonyms | Arrd2, MDM1 nuclear protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
- Nuclear protein MDM1
- zDHHC ankyrin repeat binding domain
- HR1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- Nucleus
- centrosome
- centriole
- cytosol
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- negative regulation of centriole replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- centriole
- centriolar satellite
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding