Impact Gene Summary [Mouse]
Enables actin binding activity; protein sequestering activity; and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Located in cytoplasm. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Impact |
| Official Name | impact, RWD domain protein [Source:MGI Symbol;Acc:MGI:1098233] |
| Ensembl ID | ENSMUSG00000024423 |
| Bio databases IDs | |
| Aliases | impact, RWD domain protein |
| Synonyms | E430016J11RIK, impact RWD domain protein, impact, RWD domain protein, RWDD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Impact often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uncharacterized protein family UPF0029
- RWD, DRWD, and ELF domain family
- actin binding
- RWD domain
- ribosome binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
role in cell
- differentiation
- outgrowth
- response by
- outgrowth in
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Impact gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of protein phosphorylation
- cellular response to amino acid starvation
- positive regulation of neuron differentiation
- regulation of translational initiation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- ribosome binding