Dip2a Gene Summary [Mouse]
Enables acetate-CoA ligase activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of peptidyl-lysine acetylation; and regulation of modification of postsynaptic actin cytoskeleton. Located in dendritic spine and mitochondrion. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DIP2A (disco interacting protein 2 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Dip2a |
| Official Name | disco interacting protein 2 homolog A [Source:MGI Symbol;Acc:MGI:2385920] |
| Ensembl ID | ENSMUSG00000020231 |
| Bio databases IDs | |
| Aliases | disco interacting protein 2 homolog A |
| Synonyms | 4931420H10Rik, C21orf106, DIP2, disco-interacting protein 2 homolog A, Kiaa0184-hp, mKIAA0184 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dip2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- AMP-binding enzyme
- DMAP1-binding Domain
- Adenylate forming domain, Class I superfamily
- acetate-CoA ligase
- protein binding
- amino acid adenylation domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- cell surface
- postsynaptic region
- cellular membrane
- Mitochondria
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dip2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- positive regulation of peptidyl-lysine acetylation
- acetyl-CoA biosynthetic process
- dendritic spine morphogenesis
Cellular Component
Where in the cell the gene product is active
- membrane
- dendritic spine
- mitochondrion
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetate-CoA ligase activity