Stac3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within skeletal muscle fiber development. Located in cytoplasmic side of plasma membrane and cytosol. Part of voltage-gated calcium channel complex. Is expressed in limb musculature; somite; and tongue. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stac3 |
| Official Name | SH3 and cysteine rich domain 3 [Source:MGI Symbol;Acc:MGI:3606571] |
| Ensembl ID | ENSMUSG00000040287 |
| Bio databases IDs | |
| Aliases | SH3 and cysteine rich domain 3 |
| Synonyms | 9830125E18, CMYO13, CMYP13, MYPBB, NAM, SH3 and cysteine rich domain 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stac3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Unstructured on SH3 and cysteine-rich domain-containing protein 2
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1 domain
- protein binding
- identical protein binding
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stac3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle contraction
- neuromuscular synaptic transmission
- skeletal muscle fiber development
Cellular Component
Where in the cell the gene product is active
- T-tubule
- voltage-gated calcium channel complex
- cytosol
- synapse
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding