Stc2 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; heme binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; intracellular calcium ion homeostasis; and regulation of store-operated calcium entry. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; olfactory epithelium; and vertebral axis musculature. Orthologous to human STC2 (stanniocalcin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stc2 |
| Official Name | stanniocalcin 2 [Source:MGI Symbol;Acc:MGI:1316731] |
| Ensembl ID | ENSMUSG00000020303 |
| Bio databases IDs | |
| Aliases | stanniocalcin 2 |
| Synonyms | AW125853, mustc2, STANNIOCALCIN 2, STC2L, STCRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Stanniocalcin family
- enzyme binding
- protein homodimerization
- protein binding
- heme binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- HER2 negative hormone receptor negative breast cancer
- liver cancer
- weight gain
- osteoarthritis
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- proliferation
- signaling in
- homeostasis in
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- response to vitamin D
- decidualization
- regulation of hormone biosynthetic process
- response to peptide hormone stimulus
- embryo implantation
- cellular calcium ion homeostasis
- negative regulation of gene expression
- response to oxidative stress
- endoplasmic reticulum unfolded protein response
- cellular response to hypoxia
- regulation of store-operated calcium entry
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- perinuclear region of cytoplasm
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- hormone activity
- heme binding
- enzyme binding