Pebp1 Gene Summary [Mouse]
Predicted to enable ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Acts upstream of or within sperm capacitation. Located in cell surface. Is expressed in cerebral cortex ventricular layer; cortical plate; embryo; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pebp1 |
| Official Name | phosphatidylethanolamine binding protein 1 [Source:MGI Symbol;Acc:MGI:1344408] |
| Ensembl ID | ENSMUSG00000032959 |
| Bio databases IDs | |
| Aliases | phosphatidylethanolamine binding protein 1 |
| Synonyms | HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, LOC100506570, PBP, Pbp1, Pbpr, PEBP, Phosphatidylethanolamine-binding, phosphatidylethanolamine binding protein 1, RKIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pebp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylethanolamine binding domain
- kinase binding
- lipid binding
- protein kinase binding
- phosphatidylethanolamine binding
- ATP binding
- enzyme binding
- protein binding
- receptor binding
- Phosphatidylethanolamine-binding protein
- PhosphatidylEthanolamine-Binding Protein (PEBP) domain
- mek binding domain
Pathways
Biological processes and signaling networks where the Pebp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- asthma
- septic shock
- heart failure
- experimentally-induced heart failure
- chronic sinusitis
- hepatitis B virus-related hepatocellular carcinoma
- androgenic alopecia
- aortic valve calcification
role in cell
- cell death
- proliferation
- phosphorylation in
- expression in
- apoptosis
- invasion
- activation in
- production in
- inhibition in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- dendrite tip
- cell surface
- cell borders
- Extracellular Space
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- mitochondrial outer membrane
- dendritic spines
- synaptic vesicles
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pebp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- serine-type endopeptidase inhibitor activity
- phosphatidylethanolamine binding
- protein binding
- RNA binding
- enzyme binding