Shc2 Gene Summary [Mouse]
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; sensory organ; skeleton; and skin. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Shc2 |
| Official Name | SHC (Src homology 2 domain containing) transforming protein 2 [Source:MGI Symbol;Acc:MGI:106180] |
| Ensembl ID | ENSMUSG00000020312 |
| Bio databases IDs | |
| Aliases | SHC (Src homology 2 domain containing) transforming protein 2 |
| Synonyms | 6720466E06, SCK, SHC adaptor protein 2, SHCB, SHC (Src homology 2 domain containing) transforming protein 2, SLI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Shc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Breast Cancer Regulation by Stathmin1
- CREB Signaling in Neurons
- Endothelin-1 Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Gαi Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- NGF Signaling
- Renin-Angiotensin Signaling
- Role of NFAT in Cardiac Hypertrophy
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor tyrosine kinase binding