Fgfbp1 Gene Summary [Mouse]
Enables fibroblast growth factor binding activity. Acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of myoblast proliferation. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and skin. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfbp1 |
| Official Name | fibroblast growth factor binding protein 1 [Source:MGI Symbol;Acc:MGI:1096350] |
| Ensembl ID | ENSMUSG00000048373 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor binding protein 1 |
| Synonyms | Fbp, FGF-BP, fibroblast growth factor binding protein 1, HBP17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgfbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FGF binding protein 1 (FGF-BP1)
- fibroblast growth factor binding
- heparin binding domain
- protein binding
- FGF binding domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- non-insulin-dependent diabetes mellitus
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- Alzheimer disease
- osteoarthritis
- major depression
- epidermal hyperplasia
regulates
- AKT
- MAPK
- ERK
- Fgfbp
- FGFBP1
role in cell
- phosphorylation in
- proliferation
- growth
- chemotaxis
- colony formation
- mitogenesis
- transactivation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgfbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- myoblast proliferation
- cell-cell signaling
- positive regulation of myoblast proliferation
- fibroblast growth factor receptor signaling pathway
- positive regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- heparin binding
- fibroblast growth factor binding