Dbnl Gene Summary [Mouse]
Enables actin filament binding activity and protein domain specific binding activity. Involved in neuron projection morphogenesis; podosome assembly; and synapse assembly. Acts upstream of or within Rac protein signal transduction. Located in several cellular components, including lamellipodium; podosome; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human DBNL (drebrin like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbnl |
| Official Name | drebrin-like [Source:MGI Symbol;Acc:MGI:700006] |
| Ensembl ID | ENSMUSG00000020476 |
| Bio databases IDs | |
| Aliases | drebrin-like |
| Synonyms | ABP1, drebrin-like, HIP-55, MABP1, SH3P7, Similar to drebrin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dbnl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cofilin/tropomyosin-type actin-binding protein
- flexible domain
- helical domain
- protein domain specific binding
- protein binding
- enzyme activator activity
- Src Homology 3 domain superfamily
- actin filament binding
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- actin-binding domain
- structural constituent of cytoskeleton
- actin binding
- actin depolymerizing factor homology domain
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- paralysis
- acute coronary syndrome
- Parkinson disease
- generalized edema
- tremor
- pulmonary emphysema
- motor dysfunction or movement disorder
- dyspnea
role in cell
- cellular infiltration
- formation
- formation in
- morphogenesis
- invasion by
- assembly
- cleavage in
- length
- cleavage
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- intracellular membrane-bounded organelle
- ruffle
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- presynaptic regions
- cell surface
- Extracellular Space
- postsynaptic region
- organelle lumens
- podosomes
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- cytosol
- membrane ruffles
- neurites
- secretory vesicles
- cellular protrusions
- perikaryon
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dbnl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- membrane organization
- synapse assembly
- neuron projection morphogenesis
- adaptive immune response
- endocytosis
- podosome assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- Golgi membrane
- extracellular region
- perikaryon
- plasma membrane
- podosome
- dendrite
- early endosome
- extracellular vesicular exosome
- anchoring junction
- cytoplasm
- cell cortex
- intracellular membrane-bounded organelle
- membrane
- ruffle
- cytosol
- secretory granule lumen
- lamellipodium
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein domain specific binding
- protein binding
- actin binding
- cadherin binding
- enzyme activator activity