Ppm1d Gene Summary [Mouse]
Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Involved in DNA methylation-dependent constitutive heterochromatin formation. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppm1d |
| Official Name | protein phosphatase 1D magnesium-dependent, delta isoform [Source:MGI Symbol;Acc:MGI:1858214] |
| Ensembl ID | ENSMUSG00000020525 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1D magnesium-dependent, delta isoform |
| Synonyms | IDDGIP, JDVS, PP2C-DELTA, PP2C-δ, Ppm1d predicted, protein phosphatase 1D magnesium-dependent, delta isoform, protein phosphatase 1D magnesium-dependent, δ isoform, protein phosphatase, Mg2+/Mn2+ dependent 1D, protein phosphatase, Mg2+/Mn2+ dependent, 1D, PTP delta P1, PTP δ P1, WIP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppm1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase binding
- Protein phosphatase 2C
- phosphoprotein phosphatase
- catalytic domain
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- Serine/threonine phosphatases, family 2C, catalytic domain
- PP2Cc
Pathways
Biological processes and signaling networks where the Ppm1d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- neoplasia
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- lung cancer
- central nervous system cancer
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- migration
- cell death
- binding in
- accumulation in
- activation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppm1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- peptidyl-threonine dephosphorylation
- negative regulation of gene expression, epigenetic
- G2/M transition of mitotic cell cycle
- regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of cell proliferation
- protein dephosphorylation
- DNA damage response, signal transduction by p53 class mediator
- response to radiation
- cellular response to starvation
- methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- protein serine/threonine kinase activity
- mitogen-activated protein kinase binding
- myosin phosphatase activity