Tom1l1 Gene Summary [Mouse]
Enables protein kinase activator activity. Predicted to be involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in endosome and membrane. Is expressed in several structures, including adrenal gland; nervous system; nose; submandibular gland primordium; and vibrissa. Orthologous to human TOM1L1 (target of myb1 like 1 membrane trafficking protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tom1l1 |
| Official Name | target of myb1-like 1 (chicken) [Source:MGI Symbol;Acc:MGI:1919193] |
| Ensembl ID | ENSMUSG00000020541 |
| Bio databases IDs | |
| Aliases | target of myb1-like 1 (chicken) |
| Synonyms | 2310045L10Rik, OK/KNS-CL.3, RGD1562626, SRCASM, target of myb1-like 1 (chicken), target of myb1 like 1 membrane trafficking protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tom1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- protein kinase activator
- protein kinase binding
- clathrin box motif
- clathrin binding
- PTAP motif
- VHS, ENTH and ANTH domain superfamily
- ubiquitin binding
- PSAP motif
- protein binding
- GAT domain
- Domain present in VPS-27, Hrs and STAM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- skin squamous cell carcinoma
- squamous cell skin cancer
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal membrane fractions
- endosomes
- lysosome
- cytosol
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tom1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- positive regulation of protein autophosphorylation
- signal transduction
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein transport
- regulation of DNA biosynthetic process
- activation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- cytoplasm
- membrane
- cytosol
- endosome membrane
- Golgi stack
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- protein kinase activator activity
- phosphatidylinositol binding
- clathrin binding
- SH3 domain binding