TOM1L1 Gene Summary [Human]
Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TOM1L1 |
| Official Name | target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] |
| Ensembl ID | ENSG00000141198 |
| Bio databases IDs | |
| Aliases | target of myb1 like 1 membrane trafficking protein |
| Synonyms | 2310045L10Rik, OK/KNS-CL.3, RGD1562626, SRCASM, target of myb1-like 1 (chicken), target of myb1 like 1 membrane trafficking protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOM1L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- protein kinase activator
- protein kinase binding
- clathrin box motif
- clathrin binding
- PTAP motif
- VHS, ENTH and ANTH domain superfamily
- ubiquitin binding
- PSAP motif
- protein binding
- GAT domain
- Domain present in VPS-27, Hrs and STAM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- skin squamous cell carcinoma
- squamous cell skin cancer
role in cell
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal membrane fractions
- endosomes
- lysosome
- cytosol
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOM1L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- positive regulation of protein autophosphorylation
- signal transduction
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein transport
- regulation of DNA biosynthetic process
- activation of protein kinase activity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- cytoplasm
- membrane
- cytosol
- endosome membrane
- Golgi stack
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- protein kinase activator activity
- phosphatidylinositol binding
- clathrin binding
- SH3 domain binding