Vav2 Gene Summary [Mouse]
This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Vav2 |
| Official Name | vav 2 oncogene [Source:MGI Symbol;Acc:MGI:102718] |
| Ensembl ID | ENSMUSG00000009621 |
| Bio databases IDs | |
| Aliases | vav 2 oncogene |
| Synonyms | 2810040F13Rik, LOC108350342, PP3781, vav 2 oncogene, vav guanine nucleotide exchange factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vav2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Calponin homology domain
- epidermal growth factor receptor binding
- phosphotyrosine binding
- protein binding
- Pleckstrin homology-like domain
- acidic domain
- RhoGEF domain
- Src Homology 3 domain superfamily
- inter-SH2 domain
- RhoGEF
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- PH domain
- calponin homology (CH) domain superfamily
- Src homology 2 (SH2) domain
- zinc finger domain
- Dbl homology domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Vav2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- B Cell Receptor Signaling
- Cdc42 Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Epithelial Adherens Junction Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Protein Signaling Mediated by Tubby
- Gα12/13 Signaling
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- T Cell Receptor Signaling
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- glaucoma
- neoplasia
- hyperplasia
- metastasis
- hypertension
- non-insulin-dependent diabetes mellitus
- cardiac fibrosis
- fibrosis
- hydrocephalus
phenotypes
- decreased heart left ventricle size
- thin ventricular wall
- abnormal adrenal gland secretion
- abnormal aorta tunica media morphology
- abnormal bradykinin level
- abnormal class switch recombination
- abnormal heart morphology
- abnormal iridocorneal angle
- abnormal physiological response to xenobiotic
- adrenal medulla hyperplasia
- anterior iris synechia
- cardiac fibrosis
- decreased B cell number
- decreased B cell proliferation
- decreased IgG1 level
- decreased IgG2b level
- decreased IgG3 level
- decreased IgM level
- decreased creatinine clearance
- decreased mature B cell number
- decreased spleen germinal center number
- decreased urine sodium level
- enlarged adrenal medulla
- enlarged myocardial fiber
- heart left ventricle hypertrophy
- hydrocephaly
- hypertension
- increased circulating adrenaline level
- increased circulating aldosterone level
- increased circulating antidiuretic hormone level
- increased circulating noradrenaline level
- increased circulating renin level
- increased heart rate
- increased mean systemic arterial blood pressure
- increased renin activity
- ocular hypertension
- oliguria
- renal fibrosis
- vascular smooth muscle hyperplasia
role in cell
- cell death
- activation in
- expression in
- growth
- proliferation
- adhesion
- phosphorylation in
- activity
- formation
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vav2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- small GTPase mediated signal transduction
- regulation of cell size
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- vascular endothelial growth factor receptor signaling pathway
- angiogenesis
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- lamellipodium assembly
- cellular response to xenobiotic stimulus
- cell migration
- platelet activation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- metal ion binding
- guanyl-nucleotide exchange factor activity
- epidermal growth factor receptor binding