Mmp28 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of macrophage chemotaxis. Located in cytoplasm. Is expressed in several structures, including heart; hindlimb; lung; nervous system; and skin. Orthologous to human MMP28 (matrix metallopeptidase 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp28 |
| Official Name | matrix metallopeptidase 28 (epilysin) [Source:MGI Symbol;Acc:MGI:2153062] |
| Ensembl ID | ENSMUSG00000020682 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 28 (epilysin) |
| Synonyms | D130023P12, EPILYSIN, LOC100912318, LOC103694864, matrix metallopeptidase 28, matrix metallopeptidase 28 (epilysin), MM28, MMP-25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmp28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative peptidoglycan binding domain
- Hemopexin-like repeats
- Matrixin
- ZnMc
- peptidase
- HX
- Zinc-dependent metalloprotease
- protein binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp28 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- obesity
- preeclampsia
- breast cancer
- osteoarthritis
- lung cancer
- infection by bacteria
role in cell
- chemotaxis
- invasion by
- response
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmp28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- extracellular matrix organization
- collagen catabolic process
- negative regulation of macrophage chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- metalloendopeptidase activity