Rph3al Gene Summary [Mouse]
Predicted to enable LIM domain binding activity. Involved in glucose homeostasis and positive regulation of insulin secretion. Acts upstream of or within negative regulation of G protein-coupled receptor signaling pathway and regulation of calcium ion-dependent exocytosis. Predicted to be located in secretory granule. Predicted to be active in synapse. Orthologous to human RPH3AL (rabphilin 3A like (without C2 domains)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rph3al |
| Official Name | rabphilin 3A-like (without C2 domains) [Source:MGI Symbol;Acc:MGI:1923492] |
| Ensembl ID | ENSMUSG00000020847 |
| Bio databases IDs | |
| Aliases | rabphilin 3A-like (without C2 domains) |
| Synonyms | 6530413F01RIK, AI551877, Gm1753, NOC2, rabphilin 3A-like (without C2 domains) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rph3al often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- LIM-domain binding
- cytoskeletal protein binding
- Rab binding domain
- PHD finger superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- insulin
- D-glucose
- Ins1
disease
- papillary thyroid carcinoma
- systemic lupus erythematosus
- idiopathic intracranial hypertension
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- papillary thyroid cancer
- nonalcoholic fatty liver disease
- age-related macular degeneration
- pancytopenia
role in cell
- accumulation
- growth
- exocytosis by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rph3al gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- glucose homeostasis
- positive regulation of insulin secretion
- intracellular protein transport
- regulation of calcium ion-dependent exocytosis
- exocytosis
- negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- transport vesicle membrane
- cytoplasm
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- small GTPase binding
- cytoskeletal protein binding