Rab8a Gene Summary [Mouse]
Predicted to enable several functions, including enzyme binding activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in cilium assembly and protein localization to cilium. Located in several cellular components, including ciliary base; ciliary membrane; and cytoplasmic vesicle. Is expressed in brain; liver; neural retina; and small intestine. Orthologous to human RAB8A (RAB8A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab8a |
| Official Name | RAB8A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:96960] |
| Ensembl ID | ENSMUSG00000003037 |
| Bio databases IDs | |
| Aliases | RAB8A, member RAS oncogene family |
| Synonyms | MEL, RAB8, RAB8A, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- alpha helix
- enzyme binding
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- myosin binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rab8a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- cachexia
- sickle cell anemia
- cleft lip
- diarrhea
- productive infection by HIV-1
role in cell
- plasticity
- accumulation
- proliferation
- growth
- differentiation
- formation
- formation in
- activation in
- organization
- anchoring
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- ciliary membrane
- glutaminergic synapse
- cytoplasmic vesicle membrane
- exocytic vesicle
- non-motile cilium
- cilia
- Golgi region
- cell periphery
- perinuclear region
- actin cytoskeleton
- basal bodies
- vesicles
- centrosome
- Golgi Apparatus
- midbody
- granules
- cytosol
- membrane ruffles
- Golgi membrane
- Golgi stacks
- trans Golgi network
- endosomal membrane
- nucleoplasm
- nucleoli
- alpha granules
- dendritic spines
- neurites
- synapse
- recycling endosomes
- cytoplasmic vesicles
- membrane blebs
- secretory vesicles
- cellular protrusions
- filopodia
- perikaryon
- dendrites
- postsynaptic density
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- Golgi organization
- exocytosis
- protein secretion
- cellular response to insulin stimulus
- Golgi vesicle fusion to target membrane
- regulation of protein transport
- regulation of long-term neuronal synaptic plasticity
- autophagy
- axonogenesis
- vesicle docking involved in exocytosis
- regulation of autophagy
- protein localization in plasma membrane
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cilium basal body
- synaptic vesicle
- trans-Golgi network transport vesicle
- phagocytic vesicle
- Golgi membrane
- neuronal cell body
- plasma membrane
- centrosome
- endosome
- extracellular vesicular exosome
- centriole
- dendritic spine
- cilium
- phagocytic vesicle membrane
- cytosol
- endosome membrane
- cilium membrane
- recycling endosome membrane
- midbody
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding
- small GTPase binding
- myosin V binding