Zdhhc3 Gene Summary [Mouse]
Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; positive regulation of GABAergic synaptic transmission; and positive regulation of receptor localization to synapse. Acts upstream of or within protein targeting. Located in Golgi apparatus. Is expressed in central nervous system; early conceptus; genitourinary system; and ileum. Orthologous to human ZDHHC3 (zinc finger DHHC-type palmitoyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Zdhhc3 |
| Official Name | zinc finger, DHHC domain containing 3 [Source:MGI Symbol;Acc:MGI:1926134] |
| Ensembl ID | ENSMUSG00000025786 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 3 |
| Synonyms | 1110020O22Rik, 1810006O10Rik, 2210017C02Rik, DHHC-3, FLJ20209, GODZ, Gramp1, Zfp373, zinc finger, DHHC domain containing 3, zinc finger DHHC-type palmitoyltransferase 3, ZNF373 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- DHHC motif
- peptidase
- protein homodimerization
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- cardiomyopathy
role in cell
- phosphorylation in
- expression in
- binding in
- activation in
- outgrowth
- outgrowth in
- binding
- palmitoylation in
- loss in
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synaptic transmission, GABAergic
- positive regulation of toll-like receptor 9 signaling pathway
- peptidyl-L-cysteine S-palmitoylation
- protein localization in membrane
- protein palmitoylation
- regulation of G-protein coupled receptor protein signaling pathway
- protein targeting to membrane
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein homodimerization activity
- protein-cysteine S-myristoyltransferase activity
- palmitoyltransferase activity