Edem1 Gene Summary [Mouse]
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol and trimming of terminal mannose on C branch. Acts upstream of or within ERAD pathway. Located in endoplasmic reticulum membrane. Is expressed in embryo and liver. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Edem1 |
| Official Name | ER degradation enhancer, mannosidase alpha-like 1 [Source:MGI Symbol;Acc:MGI:2180139] |
| Ensembl ID | ENSMUSG00000030104 |
| Bio databases IDs | |
| Aliases | ER degradation enhancer, mannosidase alpha-like 1 |
| Synonyms | A130059K23Rik, EDEM, ER degradation enhancer, mannosidase alpha-like 1, ER degradation enhancer, mannosidase α-like 1, ER degradation enhancing alpha-mannosidase like protein 1, ER degradation enhancing α-mannosidase like protein 1, KIAA0212, mKIAA0212, RGD1563633 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Edem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Edem1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- production in
- expression in
- degradation in
- accumulation in
- stabilization in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Edem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- mannoprotein catabolic process
- protein targeting to ER
- response to unfolded protein
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum quality control compartment
- endoplasmic reticulum
- aggresome
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
- misfolded protein binding