Hoxb9 Gene Summary [Mouse]
Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system development; mammary gland development; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early embryo; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HOXB9 (homeobox B9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxb9 |
| Official Name | homeobox B9 [Source:MGI Symbol;Acc:MGI:96190] |
| Ensembl ID | ENSMUSG00000020875 |
| Bio databases IDs | |
| Aliases | homeobox B9 |
| Synonyms | homeo box B9, HOX2, HOX-2.5, HOX2E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxb9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Hox9 activation region
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxb9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- organismal death
- hypoplasia
- breast carcinoma
- hepatocellular carcinoma
- metastasis
- clear cell sarcoma of the kidney
- renal cancer
role in cell
- expression in
- quantity
- proliferation
- invasion
- apoptosis
- migration
- phosphorylation in
- differentiation
- motility
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxb9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mammary gland development
- transcription, DNA-dependent
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- proximal/distal pattern formation
- cell chemotaxis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity