Cd33 Gene Summary [Mouse]
Predicted to enable protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to several human genes including CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd33 |
| Official Name | CD33 antigen [Source:MGI Symbol;Acc:MGI:99440] |
| Ensembl ID | ENSMUSG00000004609 |
| Bio databases IDs | |
| Aliases | CD33 antigen |
| Synonyms | CD33 ANTIGEN, CD33 molecule, CD33rSiglec, gp67, p67, SIGLEC-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- Immunoglobulin V-Type
- immunoglobulin domain
- protein phosphatase binding
- ectodomain
- protein binding
- protein tyrosine phosphatase activator
- binding protein
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- cytosolic tail domain
- membrane-proximal domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- de novo myelodysplastic syndrome
- favorable-risk acute myeloid leukemia
- acute myeloid leukemia
- extramedullary acute myeloid leukemia
- favorable-risk core binding factor acute myeloid leukemia
- Alzheimer disease
- de novo acute myeloid leukemia
- relapsed acute myeloid leukemia
- myelodysplastic syndrome
role in cell
- apoptosis
- survival
- production in
- phosphorylation in
- expression in
- proliferation
- activation
- differentiation
- binding in
- deposition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- endosomes
- Golgi Apparatus
- tertiary granule membrane
- specific granule membrane
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-inhibiting signal transduction
- signal transduction
- negative regulation of cell proliferation
- negative regulation of interleukin-8 production
- negative regulation of interleukin-1 beta production
- cell-cell signaling
- Fc-gamma receptor signaling pathway
- cell adhesion
- positive regulation of protein secretion
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- peroxisome
- external side of plasma membrane
- Golgi apparatus
- plasma membrane
- tertiary granule membrane
- nucleoplasm
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein tyrosine phosphatase activator activity
- protein phosphatase binding
- protein binding
- signaling receptor activity
- sialic acid binding
- carbohydrate binding