Akr1c21 Gene Summary [Mouse]
Enables NADP binding activity; lithocholic acid binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akr1c21 |
| Official Name | aldo-keto reductase family 1, member C21 [Source:MGI Symbol;Acc:MGI:1924587] |
| Ensembl ID | ENSMUSG00000021207 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1, member C21 |
| Synonyms | 3-alpha HSD3, 3-α HSD3, 9430025F20Rik, Akr1c21, AKR1C-pseudo, Aldo-keto reductase, aldo-keto reductase family 1 member C2, aldo-keto reductase family 1, member C2, aldo-keto reductase family 1, member C21, BABP, DD, DD-2, DD/BABP, DDH2, HAKRD, HBAB, Hepatic Bile Acid Binding, LOC100134257, LOC100508006, LOC100653286, MCDR2, RAKg, SRXY8, TDD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akr1c21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3beta(or 20alpha)-hydroxysteroid dehydrogenase
- Aldo-keto reductase (AKR) superfamily
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- retinal dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- ketosteroid monooxygenase
- steroid binding
- 3alpha-hydroxysteroid dehydrogenase (A-specific)
- NADPH binding
- binding protein
- NADP binding
- aldo-keto reductase
- chlordecone reductase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- 3alpha-hydroxysteroid dehydrogenase (B-specific)
- steroid dehydrogenase
- aldehyde reductase
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the Akr1c21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- 46,XY sex reversal type 8
- metastatic colorectal cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- breast cancer
- carpal tunnel syndrome
regulates
- (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene
- trans-(±)-3,5-cyclohexadiene-1,2-diol
- 9,10-phenanthrenequinone
- allopregnanolone
- 5alpha-dihydroprogesterone
- (±)-trans-3,4-dihydroxy-3,4-dihydro-benzo[c]phenanthrene
- steroid
- dihydrotestosterone
- 3-alpha,17-beta-androstanediol
- (±)-trans-3,4-dihydroxy-3,4-dihydro-7-methylbenz[a]anthracene
role in cell
- proliferation
- cross-linkage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akr1c21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- progesterone metabolic process
- G-protein coupled receptor signaling pathway
- positive regulation of cell proliferation
- digestion
- daunorubicin metabolic process
- steroid metabolic process
- prostaglandin metabolic process
- doxorubicin metabolic process
- epithelial cell differentiation
- cellular response to jasmonic acid stimulus
- cellular response to prostaglandin D stimulus
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- carboxylic acid binding
- phenanthrene 9,10-monooxygenase activity
- estradiol 17-beta-dehydrogenase activity
- indanol dehydrogenase activity
- ketosteroid monooxygenase activity
- bile acid binding
- androsterone dehydrogenase activity
- alditol:NADP+ 1-oxidoreductase activity
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor