Sirt7 Gene Summary [Mouse]
Enables NAD-dependent protein-lysine depropionylase activity and histone H3K18 deacetylase activity, NAD-dependent. Involved in several processes, including chromatin remodeling; homologous chromosome pairing at meiosis; and protein deacylation. Located in chromatin and site of double-strand break. Is expressed in several structures, including 1st branchial arch maxillary component; central nervous system; eye; gonad; and pancreas. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sirt7 |
| Official Name | sirtuin 7 [Source:MGI Symbol;Acc:MGI:2385849] |
| Ensembl ID | ENSMUSG00000025138 |
| Bio databases IDs | |
| Aliases | sirtuin 7 |
| Synonyms | SIR2L7, sirtuin 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sirt7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- NAD-dependent histone deacetylase
- histone deacetylase
- chromatin binding
- enzyme
- protein binding
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the Sirt7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- cardiac fibrosis
- leukopenia
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- tumorigenesis
role in cell
- expression in
- molecular cleavage in
- invasion by
- phosphorylation in
- cell death
- damage in
- apoptosis
- migration
- number
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sirt7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of gene expression, epigenetic
- peptidyl-lysine demalonylation
- positive regulation of gene expression, epigenetic
- regulation of DNA repair
- rRNA transcription
- protein deacetylation
- response to DNA damage stimulus
- regulation of protein export from nucleus
- synapsis
- positive regulation of gluconeogenesis
- regulation of gene expression, epigenetic
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase I promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transposition, RNA-mediated
- positive regulation of rRNA processing
- osteoblast differentiation
- negative regulation of protein ubiquitination
- regulation of mitochondrion organization
- peptidyl-lysine desuccinylation
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
- nuclear speck
- nucleolus
- chromatin
- nucleolus organizer region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NAD-dependent protein deacetylase activity
- protein binding
- protein methyltransferase activity
- metal ion binding
- protein-malonyllysine demalonylase activity
- protein-succinyllysine desuccinylase activity
- chromatin binding
- NAD+ binding