Kif2a Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in dendritic transport. Located in sperm principal piece. Is active in GABA-ergic synapse. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif2a |
| Official Name | kinesin family member 2A [Source:MGI Symbol;Acc:MGI:108390] |
| Ensembl ID | ENSMUSG00000021693 |
| Bio databases IDs | |
| Aliases | kinesin family member 2A |
| Synonyms | C530030B14RIK, CDCBM3, HK2, KHC2, KIF2, Kinesin 2, kinesin family member 2A, KNS2, M-kinesin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- protein kinase binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- protein binding
- motor protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- complex cortical dysplasia with other brain malformations 3
- neurodegeneration
role in cell
- migration
- proliferation
- formation
- formation in
- invasion by
- survival
- degradation in
- outgrowth
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- cell cortex
- Nucleus
- basal bodies
- vesicles
- centrosome
- lysosome
- centriole
- microtubules
- midbody
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- spindle pole
- spindle fibers
- synapse
- cytoplasmic vesicles
- central spindle
- mitotic spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- mitotic spindle organization
- cell differentiation
- nervous system development
- microtubule cytoskeleton organization
- microtubule-based movement
- regulation of cell migration
- microtubule depolymerization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- spindle pole
- kinesin complex
- nucleolus
- microtubule
- nucleoplasm
- spindle microtubule
- centrosome
- centriole
- cytoplasm
- membrane
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein binding
- motor activity
- microtubule binding