Fezf2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell dedifferentiation; positive regulation of DNA-templated transcription; and regulation of neurogenesis. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future prosencephalon; retina; thymus; and vomeronasal organ. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fezf2 |
| Official Name | Fez family zinc finger 2 [Source:MGI Symbol;Acc:MGI:1859823] |
| Ensembl ID | ENSMUSG00000021743 |
| Bio databases IDs | |
| Aliases | Fez family zinc finger 2 |
| Synonyms | FEZ, FEZ family zinc finger 2, FEZL, FKSG36, TOF, ZFP312, ZNF312 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fezf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- chromatin binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperactive behavior
- growth failure
- neurodevelopmental disorder
- productive infection by HIV-1
role in cell
- expression in
- proliferation
- apoptosis
- differentiation
- number
- development
- guidance
- morphology
- size
- fasciculation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fezf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- commitment of neuronal cell to specific neuron type in forebrain
- negative regulation of cell proliferation
- negative regulation of neuron differentiation
- forebrain anterior/posterior pattern specification
- positive regulation of neuron differentiation
- cerebral cortex GABAergic interneuron migration
- cell dedifferentiation
- positive regulation of transcription from RNA polymerase II promoter
- dentate gyrus development
- axonal fasciculation
- negative regulation of transcription from RNA polymerase II promoter
- locomotory behavior
- neuron fate determination
- regulation of gene expression
- regulation of neurogenesis
- dendrite development
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription