Bhlhe22 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and identical protein binding activity. Acts upstream of or within cerebral cortex regionalization; negative regulation of DNA-templated transcription; and neuron differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human BHLHE22 (basic helix-loop-helix family member e22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bhlhe22 |
| Official Name | basic helix-loop-helix family, member e22 [Source:MGI Symbol;Acc:MGI:1930001] |
| Ensembl ID | ENSMUSG00000025128 |
| Bio databases IDs | |
| Aliases | basic helix-loop-helix family, member e22 |
| Synonyms | basic helix-loop-helix family member e22, basic helix-loop-helix family, member e22, Beta3, Beta3a, BHLHB5, CAGL85, TNRC20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bhlhe22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- chromatin binding
- protein binding
- Helix-loop-helix DNA-binding domain
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bhlhe22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron fate commitment
- positive regulation of transcription from RNA polymerase II promoter
- sensory organ development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein dimerization activity
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity