Anxa11 Gene Summary [Mouse]
Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and phosphatidylethanolamine binding activity. Predicted to be involved in cytokinetic process; phagocytosis; and response to calcium ion. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anxa11 |
| Official Name | annexin A11 [Source:MGI Symbol;Acc:MGI:108481] |
| Ensembl ID | ENSMUSG00000021866 |
| Bio databases IDs | |
| Aliases | annexin A11 |
| Synonyms | A830099O17Rik, ALS23, ANNEXIN11, annexin A11, ANX11, CAP-50, Gm2260, Gm2274, IBMWMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anxa11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- phosphatidylethanolamine binding
- calcium ion binding
- calcium-dependent phospholipid binding
- Annexin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- mir-148 (includes others)
- SLC1A5
disease
- neoplasia
- amyotrophic lateral sclerosis
- colon cancer
- colorectal cancer
- sarcoidosis
- amyotrophic lateral sclerosis type 23
- inclusion body myopathy and brain white matter abnormalities
- oculopharyngeal muscular dystrophy
- Waldenström macroglobulinemia
- chronic obstructive pulmonary disease
role in cell
- growth
- expression in
- apoptosis
- proliferation
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- mitotic microtubule
- intracellular membrane-bounded organelle
- spindle apparatus
- Cytoplasm
- centrosome
- midbody
- cytosol
- nucleoplasm
- nuclear envelope
- azurophil granules
- specific granules
- mitotic spindle
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anxa11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokinetic process
- response to calcium ion
- phagocytosis
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- plasma membrane
- nucleoplasm
- nuclear envelope
- nucleus
- extracellular vesicular exosome
- melanosome
- cytoplasm
- specific granule
- vesicle membrane
- membrane
- azurophil granule
- spindle
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- phosphatidylserine binding
- protein binding
- RNA binding
- calcium ion binding
- calcium-dependent protein binding
- MHC class II protein complex binding
- S100 protein binding
- calcium-dependent phospholipid binding