Sh3bp5 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasmic vesicle membrane; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Sh3bp5 |
| Official Name | SH3-domain binding protein 5 (BTK-associated) [Source:MGI Symbol;Acc:MGI:1344391] |
| Ensembl ID | ENSMUSG00000021892 |
| Bio databases IDs | |
| Aliases | SH3-domain binding protein 5 (BTK-associated) |
| Synonyms | SAB, SH3-domain binding protein 5, SH3-domain binding protein 5 (BTK-associated), Vesp18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh3bp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SH3 domain-binding protein 5 (SH3BP5)
- protein kinase inhibitor activity
- guanyl-nucleotide exchange factor
- protein binding
- SH3-domain binding
- Bruton's tyrosine kinase binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial premature complex
role in cell
- activation in
- cell death
- necrosis
- signal transduction in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- Mitochondria
- mitochondrial outer membrane
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh3bp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- nuclear body
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- SH3 domain binding
- protein kinase inhibitor activity