Samsn1 Gene Summary [Mouse]
Predicted to enable phosphotyrosine residue binding activity. Involved in negative regulation of B cell activation; negative regulation of adaptive immune response; and negative regulation of peptidyl-tyrosine phosphorylation. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; embryo mesenchyme; nervous system; sensory organ; and surface ectoderm. Orthologous to human SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Samsn1 |
| Official Name | SAM domain, SH3 domain and nuclear localization signals, 1 [Source:MGI Symbol;Acc:MGI:1914992] |
| Ensembl ID | ENSMUSG00000022876 |
| Bio databases IDs | |
| Aliases | SAM domain, SH3 domain and nuclear localization signals, 1 |
| Synonyms | 4930571B16Rik, 930571B16Rik, Hacs1, SAM domain, SH3 domain and nuclear localization signals, 1, SLy2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Samsn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- phosphotyrosine binding
- Lymphocyte signaling adaptor protein
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- quantity
- proliferation
- expression in
- production in
- polarization
- function
- number
- cell spreading
- activation
- ruffling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol