Cacna2d3 Gene Summary [Mouse]
Predicted to enable voltage-gated calcium channel activity. Involved in regulation of presynapse organization. Is active in GABA-ergic synapse and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna2d3 |
| Official Name | calcium channel, voltage-dependent, alpha2/delta subunit 3 [Source:MGI Symbol;Acc:MGI:1338890] |
| Ensembl ID | ENSMUSG00000021991 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, alpha2/delta subunit 3 |
| Synonyms | alapha2delta3, Ca channel alpha2delta3 subunit, Ca channel alpha-2-delta-c subunit, Ca channel α-2-δ-c subunit, Cacnad3, calcium channel, voltage-dependent, alpha2/delta subunit 3, calcium channel, voltage-dependent, alpha2/δ subunit 3, calcium voltage-gated channel auxiliary subunit alpha2delta 3, HSA272268, LOC108353110 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacna2d3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Neuronal voltage-dependent calcium channel alpha 2acd
- von Willebrand factor (vWF) type A domain
- vWFA
- von Willebrand factor type A domain
- Sensor domains of Histidine Kinase receptors
- VWA N-terminal
- ion channel
- calcium channel regulator
Pathways
Biological processes and signaling networks where the Cacna2d3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- congestive heart failure
- disorder of coronary artery
- heart failure
- angina pectoris
- essential hypertension
- aortic stenosis
- hypertension
- variant angina
- atrial fibrillation
regulates
- Ca2+
role in cell
- synaptic transmission in
- size
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacna2d3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- voltage-gated calcium channel activity