Gpaa1 Gene Summary [Mouse]
Predicted to enable GPI-anchor transamidase activity. Predicted to contribute to GPI anchor binding activity. Predicted to be involved in attachment of GPI anchor to protein and protein-containing complex assembly. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in several cellular components, including centrosome; endoplasmic reticulum; and mitochondrion. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpaa1 |
| Official Name | GPI anchor attachment protein 1 [Source:MGI Symbol;Acc:MGI:1202392] |
| Ensembl ID | ENSMUSG00000022561 |
| Bio databases IDs | |
| Aliases | GPI anchor attachment protein 1 |
| Synonyms | GAA1, glycosylphosphatidylinositol anchor attachment 1, GPI ANCHOR ATTACHMENT protein 1, GPIBD15, hGAA1, mGAA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpaa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- GPI-anchor transamidase
- Gaa1-like, GPI transamidase component
- lumenal domain
- transmembrane domain
- enzyme
- protein binding
- cytosolic tail domain
- loop domain
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Gpaa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- centrosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpaa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- attachment of GPI anchor to protein
- protein retention in ER lumen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- centrosome
- membrane
- mitochondrion
- cytosol
- endoplasmic reticulum
- GPI-anchor transamidase complex
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- GPI-anchor transamidase activity
- GPI anchor binding