Slc7a8 Gene Summary [Mouse]
Enables L-amino acid transmembrane transporter activity; glycine transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study sensorineural hearing loss. Orthologous to human SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc7a8 |
| Official Name | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 [Source:MGI Symbol;Acc:MGI:1355323] |
| Ensembl ID | ENSMUSG00000022180 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 |
| Synonyms | LAT2, Lat4, LPI-PC1, solute carrier family 7 (cationic amino acid transporter, y+ system), member 8, solute carrier family 7 member 8, y+LAT-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc7a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alanine transporter
- leucine transporter
- glycine transporter
- L-amino acid transporter
- protein binding
- neutral amino acid transporter
- amine/polyamine transporter
- organic cation transporter
- amino acid permease
- antiporter
- L-type amino acid transporter
- toxin transporter
- thyroid hormone transporter
- protein heterodimerization
- peptide antigen binding
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cataract disease
- major depression
- squamous-cell carcinoma
- androgenic alopecia
- neuroticism
- dermatological disorder
- squamous cell cancer
role in cell
- proliferation
- expression in
- recruitment
- phosphorylation in
- phagocytosis
- frequency
- production in
- abnormal morphology
- response
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular space
- cellular membrane
- Nucleus
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- neurites
- microvilli
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc7a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- valine transport
- tryptophan transport
- glycine transport
- neutral amino acid transport
- amino acid transport
- amino acid transmembrane transport
- leucine transport
- thyroid hormone transport
- proline transmembrane transport
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- basal plasma membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- organic cation transmembrane transporter activity
- peptide antigen binding
- glycine transmembrane transporter activity
- antiporter activity
- neutral amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- L-alanine transmembrane transporter activity
- L-leucine transmembrane transporter activity
- protein binding
- protein heterodimerization activity
- thyroid hormone transmembrane transporter activity
- toxin transporter activity