Parvb Gene Summary [Mouse]
Predicted to enable actin binding activity. Predicted to be involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; liver; and sensory organ. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parvb |
| Official Name | parvin, beta [Source:MGI Symbol;Acc:MGI:2153063] |
| Ensembl ID | ENSMUSG00000022438 |
| Bio databases IDs | |
| Aliases | parvin, beta |
| Synonyms | affixin, AI595373, AW742462, CGI-56, D15Gsk1, Parvin beta, parvin, beta, Parvin β, parvin, β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parvb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH2 domain (from immunoglobulin)
- alpha actinin binding domain
- calponin homology (CH) domain superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Parvb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- lewy body disease
- cerebral hemorrhage
- osteoporosis
- proliferative diabetic retinopathy
- asthma
- productive infection by HIV-1
role in cell
- growth
- apoptosis
- adhesion
- formation
- organization
- invasion
- assembly
- cell spreading
- blebbing
- cell rounding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- focal adhesions
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
- actin stress fibers
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parvb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell projection assembly
- establishment or maintenance of cell polarity
- establishment or maintenance of cell polarity regulating cell shape
- substrate adhesion-dependent cell spreading
- lamellipodium assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- focal adhesion
- cytoplasm
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding