Irf4 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in defense response to protozoan; mononuclear cell differentiation; and positive regulation of metabolic process. Acts upstream of or within chromatin remodeling; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Part of nucleosome. Is expressed in several structures, including eye; hemolymphoid system; liver; mandible; and testis. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irf4 |
| Official Name | interferon regulatory factor 4 [Source:MGI Symbol;Acc:MGI:1096873] |
| Ensembl ID | ENSMUSG00000021356 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 4 |
| Synonyms | interferon regulatory factor 4, LSIRF, MUM-1, NF-EM5, PIP, SHEP8, Spip |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- transcription co-activator
- autoinhibitory protein domain
- regulatory domain
- DNA binding domain
- nucleic acid binding
- IRF
- Irf binding domain
- alpha helix
- Interferon-regulatory factor 3
- protein binding
- sequence-specific DNA binding
- proline rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Irf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- chronic lymphocytic leukemia
- epithelial cancer
- cancer
- refractory multiple myeloma
- multiple sclerosis
- experimental autoimmune encephalomyelitis
- uveal melanoma
- ocular melanoma
- skin neoplasm
role in cell
- expression in
- activation in
- apoptosis
- proliferation
- cellular infiltration by
- cell death
- production in
- binding in
- growth
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of toll-like receptor signaling pathway
- T cell activation
- regulation of T-helper cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- immune system process
- regulation of transcription from RNA polymerase II promoter
- defense response to protozoan
- chromatin remodeling
- positive regulation of interleukin-13 production
- positive regulation of transcription, DNA-dependent
- myeloid dendritic cell differentiation
- T-helper 17 cell lineage commitment
- positive regulation of interleukin-10 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- nucleosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- transcription coactivator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity