Polr1a Gene Summary [Mouse]
Predicted to enable DNA/RNA hybrid binding activity; chromatin binding activity; and metal ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in negative regulation of protein localization to nucleolus and rRNA transcription. Located in chromosome and nucleus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Polr1a |
| Official Name | polymerase (RNA) I polypeptide A [Source:MGI Symbol;Acc:MGI:1096397] |
| Ensembl ID | ENSMUSG00000049553 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) I polypeptide A |
| Synonyms | 2900087K15Rik, 3010014K16RIK, A190, AFDCIN, HLD27, LOC105242680, LOC90784, mRPA1, polymerase (RNA) I polypeptide A, RNA polymerase I subunit A, RPA1, RPA190, RPA194, RPO1-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase Rpb1, domain 1
- Largest subunit of RNA polymerase (RNAP), C-terminal domain
- RNA polymerase Rpb1, domain 3
- DNA-directed RNA polymerase
- nucleic acid binding
- RNA polymerase Rpb1, domain 4
- chromatin binding
- enzyme
- protein binding
- magnesium ion binding
- RNA polymerase Rpb1, domain 5
- zinc ion binding
- RNA polymerase Rpb1, domain 2
- Largest subunit of RNA polymerase (RNAP), N-terminal domain
- RNA polymerase I subunit A N-terminus
- DNA-directed RNA polymerase, subunit A''
Pathways
Biological processes and signaling networks where the Polr1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypomyelinating leukodystrophy type 27
- Cincinnati type acrofacial dysostosis
role in cell
- apoptosis
- degradation in
- cell viability
- binding in
- stabilization in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- DNA binding
- zinc ion binding
- RNA polymerase I activity
- DNA-directed RNA polymerase activity
- protein binding
- DNA/RNA hybrid binding
- chromatin binding