Rnf144a Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in pattern recognition receptor signaling pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to human RNF144A (ring finger protein 144A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rnf144a |
| Official Name | ring finger protein 144A [Source:MGI Symbol;Acc:MGI:1344401] |
| Ensembl ID | ENSMUSG00000020642 |
| Bio databases IDs | |
| Aliases | ring finger protein 144A |
| Synonyms | hUIP4, KIAA0161, RGD1561737, ring finger protein 144A, RNF144, UBCE7IP4, UIP4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf144a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRcat_Rcat_RBR
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- pervasive developmental disorder
- flu
- febrile seizure
- chronic obstructive asthma
- myopia
- cerebral aneurysm
- cerebral amyloid angiopathy
- Wegener granulomatosis
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Golgi Apparatus
- endoplasmic reticulum membrane
- endosomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf144a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein K6-linked ubiquitination
- pattern recognition receptor signaling pathway
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ubiquitin ligase complex
- cytoplasm
- intracellular membrane-bounded organelle
- endosome membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding