Arpc4 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and enzyme binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to protein-macromolecule adaptor activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Is expressed in dorsal root ganglion. Used to study psoriasis. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arpc4 |
| Official Name | actin related protein 2/3 complex, subunit 4 [Source:MGI Symbol;Acc:MGI:1915339] |
| Ensembl ID | ENSMUSG00000079426 |
| Bio databases IDs | |
| Aliases | actin related protein 2/3 complex, subunit 4 |
| Synonyms | 5330419I20Rik, actin related protein 2/3 complex subunit 4, actin related protein 2/3 complex, subunit 4, ARC20, Arp2/3 complex 20 kDa subunit, Arpc4 predicted, DEVLO, P20-ARC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arpc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- structural constituent of cytoskeleton
- ARP2/3 complex 20 kDa subunit (ARPC4)
- protein binding activity, bridging
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the Arpc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Axonal Guidance Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- FAK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Integrin Signaling
- Phagosome Formation
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- developmental delay, language impairment, and ocular abnormalities
regulates
- zymosan
- Myelin
role in cell
- formation
- formation in
- processing in
- phagocytosis by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arpc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin nucleation
- actin filament polymerization
- Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- extracellular vesicular exosome
- cytosol
- cell projection
- Arp2/3 protein complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- structural constituent of cytoskeleton
- protein binding, bridging
- enzyme binding