Zfp148 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamete generation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system. Orthologous to human ZNF148 (zinc finger protein 148). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp148 |
| Official Name | zinc finger protein 148 [Source:MGI Symbol;Acc:MGI:1332234] |
| Ensembl ID | ENSMUSG00000022811 |
| Bio databases IDs | |
| Aliases | zinc finger protein 148 |
| Synonyms | 2210405J08Rik, BERF-1, BFCOL1, GDACCF, HT-BETA, HT-β, Mt-beta, Mt-β, pHZ-52, ZBP-89, ZFP148, zinc finger protein 148, β enolase repressor factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp148 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- global developmental delay, absent or hypoplastic corpus callosum and dysmorphic facies
- hereditary disorder
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- proliferation
- apoptosis
- cell death
- quantity
- differentiation
- activation in
- generation in
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Golgi Apparatus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp148 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- cellular defense response
- negative regulation of transcription, DNA-dependent
- gamete generation
- positive regulation of transcription from RNA polymerase II promoter
- substantia nigra development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription