Fbxw8 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is active in cytosol. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxw8 |
| Official Name | F-box and WD-40 domain protein 8 [Source:MGI Symbol;Acc:MGI:1923041] |
| Ensembl ID | ENSMUSG00000032867 |
| Bio databases IDs | |
| Aliases | F-box and WD-40 domain protein 8 |
| Synonyms | 4930438M06RIK, F-box and WD-40 domain protein 8, F-box and WD repeat domain containing 8, FBW6, FBW8, FBX29, FBXO29, FBXW6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxw8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- linker domain
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- marginal zone cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- intrauterine growth retardation
role in cell
- proliferation
- degradation in
- expression in
- organization
- ubiquitination in
- K48 polyubiquitination in
- morphogenesis
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxw8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cilium morphogenesis
- labyrinthine layer blood vessel development
- Golgi organization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of dendrite morphogenesis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- centriole
- cilium basal body
- cytosol
- Golgi apparatus
- SCF ubiquitin ligase complex
- Cul7-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding