Denr Gene Summary [Mouse]
Predicted to enable translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Denr |
| Official Name | density-regulated protein [Source:MGI Symbol;Acc:MGI:1915434] |
| Ensembl ID | ENSMUSG00000023106 |
| Bio databases IDs | |
| Aliases | density-regulated protein |
| Synonyms | 1500003K04Rik, density-regulated protein, density regulated re-initiation and release factor, DRP, DRP1, LOC689601, SMAP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Denr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translation initiation factor SUI1
- protein binding
- Eukaryotic initiation factor 1 and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
role in cell
- apoptosis
- expression in
- cohesion
- cohesion in
- translation in
- mitosis in
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Denr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation preinitiation complex
- ribosome disassembly
- translation reinitiation
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- mRNA binding