Ablim1 Gene Summary [Mouse]
Enables actin binding activity. Acts upstream of or within axon guidance and positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton. Is active in postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lateral plate mesoderm; and node. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ablim1 |
| Official Name | actin-binding LIM protein 1 [Source:MGI Symbol;Acc:MGI:1194500] |
| Ensembl ID | ENSMUSG00000025085 |
| Bio databases IDs | |
| Aliases | actin-binding LIM protein 1 |
| Synonyms | 2210411C18RIK, 2610209L21Rik, 4833406P10Rik, 9330196J19RIK, ABLIM, ABLM1, actin-binding LIM protein 1, LIMAB1, LIMATIN, LOC102550100, mKIAA0059, RGD1565768 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ablim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dematin-like domain
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actin binding
- Villin headpiece domain
- protein binding
- headpiece domain
- Putative adherens-junction anchoring region of AbLIM
Pathways
Biological processes and signaling networks where the Ablim1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- epithelial neoplasia
- psoriasis
- cholangiocarcinoma cancer
- metastasis
- myotonic dystrophy type 1
- Rett syndrome
- bile duct cancer
- liver neoplasia
role in cell
- invasion by
- assembly
- growth
- pathfinding
- guidance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- actin cytoskeleton
- Mitochondria
- photoreceptor inner segments
- Z line
- actin stress fibers
- anchoring junction
- postsynaptic density
- rod inner segments
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ablim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- cilium morphogenesis
- lamellipodium assembly
- visual perception
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- stress fiber
- actin cytoskeleton
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- metal ion binding