Ube2j2 Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway; protein K6-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2j2 |
| Official Name | ubiquitin-conjugating enzyme E2J 2 [Source:MGI Symbol;Acc:MGI:2153608] |
| Ensembl ID | ENSMUSG00000023286 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2J 2 |
| Synonyms | 1200007B18Rik, 2400008G19Rik, 5730472G04Rik, NCUBE-2, PRO2121, UBC6, Ubc6p, ubiquitin-conjugating enzyme E2, J2, ubiquitin-conjugating enzyme E2J 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2j2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2j2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2j2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- response to unfolded protein
- protein K6-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- ubiquitin ligase complex
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin protein ligase binding
- protein binding